Nadezhda Korostyleva

← Selected work

MAP — microneedle phototherapy wound patch

Antimicrobial blue light kills bacteria, but it barely penetrates skin. This patch carries the light past that barrier and into the wound bed.

Acousto-Bioelectronics Lab, Dr. Albert Kim, University of South Florida
May 2025 to present — project lead
First-author paper, IEEE International Conference on MEMS 2026

30 °C
reduction in peak device temperature
100×
lower power consumption
100+
devices fabricated
1 month
from joining the lab to a first-author paper

01 — The problem

Light that stops at the surface

Blue light in the 400–470 nm band is antimicrobial and does not drive resistance the way antibiotics do, which makes it attractive for infected and chronic wounds. The difficulty is delivery. Skin and eschar scatter and absorb light heavily, so surface illumination reaches only the top layer, and reaching the wound bed by turning the source up means more heat and more power than a wearable can carry.

Micrograph of the moulded microlens array, the close-packed plano-convex lenses filling the frame with a scale bar at the lower edge.
The same close-packed lens array imaged against a dark background, showing the regular hexagonal packing across the device.

02 — The approach

Carrying the light past the barrier

Rather than illuminating the surface harder, the patch moves the light source's output through the skin barrier mechanically. A microlens array couples LED output into microneedles that penetrate the stratum corneum, so light is released at depth instead of scattering at the surface. The result is a device that reaches the wound bed at a fraction of the optical power a surface emitter would need.

I led the project end to end: device architecture, CAD, fabrication process, and the electronics that drive the array.

CAD drawing of the microneedle array: plan view with the needle pattern and registration cut-outs dimensioned, a sectional view giving the 0.10 needle height, and an isometric view of the array.
Microneedle array in CAD — plan, section and isometric views of the patterned substrate.

03 — Fabrication and drive

Built in batches

The array is produced through a cleanroom process I developed and then ran at volume, with more than a hundred devices fabricated across design iterations. Building at that count is what made the design converge: each batch surfaced yield and assembly problems that were invisible in single prototypes.

Two failure modes dominated early builds — the device ran far too hot against skin, and drew far more power than a wearable format allows. Resolving those meant reworking both the drive circuitry and the mechanical stack rather than treating them separately, since the thermal path and the electrical design are the same problem seen from two directions.

The LED source array running, individual emitters visible through the lens optic against saturated red illumination.
The source array under drive.

04 — Results

Cooler, cheaper, and it works in vitro

The redesigned device runs 30 °C cooler at peak and consumes two orders of magnitude less power than the initial build, which is what moved the concept from bench demonstration to something wearable. In vitro results were strong enough to write up within the first month of the project, published as a first-author paper at IEEE MEMS 2026. The device has since advanced through in vivo validation.

Three MAP devices illuminating wells of a six-well culture plate from beneath, each showing a three-by-three array of emitters through the plate base.
In vitro setup: MAP devices delivering red light into a six-well plate of fibroblasts.

05 — Published

IEEE MEMS 2026

The work was written up as a first-author conference paper and poster: device concept, design and fabrication, irradiance characterisation with and without the microlens array, and fibroblast scratch and viability assays showing accelerated closure and increased proliferation.

The useful lesson was that the thermal and power problems were not separate bugs to fix in sequence. They shared a root cause in how the array was driven, and finding that meant measuring the device rather than reasoning about it.

Holding the IEEE MEMS 2026 poster, titled Microneedle-Mediated Adaptive Phototherapy (MAP) Wound Patch with Microlenses.
The IEEE MEMS 2026 poster.

Next: microfluidic perfusion chamber for brain slices →